GliaSite RTS Information Request
WHAT IS GLIASITE RTS? IS GLIASITE RTS RIGHT FOR ME? PATIENT RESOURCES FOR HEALTH CARE PROFESSIONALS
About GliaSite RTS Clinical Data Procedure Case Studies Ordering Info Reimbursement
About GliaSite RTS

Local radiation therapy for malignant brain tumors

The GliaSite Radiation Therapy System (RTS) is designed for the treatment of newly diagnosed, metastatic and recurrent brain tumors by delivering radiation from within the tumor resection cavity.

The GliaSite balloon catheter is implanted within the tumor cavity at the time of resection surgery. Following a simple treatment planning protocol, the balloon is infused with Iotrex® Radiotherapy Solution, an organically bound 125I liquid radiation source that delivers a highly conformal dose of radiation to the target area.1,2

Optimal delivery

  • Delivers radiation from within the tumor resection cavity
  • Maximizes the dose of radiation to target area3-5

  • Conformal, spherically uniform dose of radiation delivered directly to areas most likely for recurrence2,6,8

  • Radiation treatment completed within 3 to 7 days

Proven performance

  • Minimizes radiation exposure to healthy brain tissue
  • Limits potential for side effects associated with external beam radiation
  • 387 day median survival from time of treatment for recurrent primary tumor1

References:

1 Tatter SB, et al. An Inflatable Balloon Catheter (GliaSite RTS Radiation Therapy System) and Liquid 125I Radiation Source for Treatment of Recurrent Malignant Glioma: Multi-center Safety and Feasibility Trial. Journal of Neurosurgery. Aug. 2003. In press.
2 Dempsey JF, et al. Dosimetric properties of a novel brachytherapy balloon applicator for the treatment of malignant brain tumor resection cavity. Int J Radiat Oncol Biol Phys. 1998;42:421-429.
3 McMullen KP, et al. Radiation safety and dosimetry for phase I study of the safety and performance of the GliaSite RTS Radiation Therapy System for brachytherapy treatment of resected malignant glioma cavities. Poster presented at: Annual Meeting of the American Society for Therapeutic Radiology and Oncology; November 2000.
4 Olson J, et al. A phase I study of brachytherapy of recurrent malignant gliomas using an inflatable balloon catheter and liquid 125I source. Presented at: Annual Meeting of Georgia Neurosurgical Society; July 2000.
5 Shaw E, et al. The GliaSite RTS Radiation Therapy System (RTS): A novel approach to brain brachytherapy for recurrent malignant glioma. Poster presented at: Annual Meeting of the American Society of Therapeutic Radiology and Oncology; 2001.
6 Frankel R, et al. Preclinical evaluation of a novel device for delivering brachytherapy to resected brain tumor cavity margins. Int J Radiat Oncol Biol Phys. 1999;45:319-320.
7 Hochberg F, et. al., Assumptions in the Radiotherapy of Glioblastoma. Neurology 1980; 30:907-911.
8 Monroe JI, et al. Experimental validation of dose calculation algorithms for the GliaSite RTS, a novel 125I liquid-filled balloon brachytherapy applicator. Med Physics,. 2001;28:73-85.
GliaSite RTS Radiation Image
Quick Links
GliaSite balloon catheter
Iotrex Radiotherapy Solution:
our proprietary radiation source
Hologic Home Page Contact Us | Privacy | Terms | Site Map
© 2005-2008 Cytyc. A Hologic Company. All Rights Reserved