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Internal Radiation Therapy

Internal radiation therapy for brain tumors (also known as brachytherapy, localized radiation, or interstitial radiation) involves placing a source of radiation directly into the tumor or the tissue surrounding the tumor. Until recently, brachytherapy involved the placement of a large number of radiation “seeds” (approximately the size of a grain of rice) directly into the cancerous tissue using numerous tube-like catheters.

The major benefit of internal radiation is that a high dose of radiation may be given directly to the tumor site. The radiation is targeted in the area most likely to contain cancer. At the same time, healthy tissue around the tumor is less likely to be damaged by radiation. Good clinical results have been documented using this type of radiation therapy. 1,2,3

Unlike external beam radiation, internal radiation therapy does not require the radiation to pass through healthy tissue to reach the cancerous area. Because of this, internal radiation is an option even for patients who have already had external beam radiation. This approach can be used to deliver radiation to a recurrent brain tumor. Internal radiation therapy can also provide a boost dose (additional radiation dose) targeted to the tumor site with external beam radiation for initial tumor treatment.

However, until now the complexity and complications associated with internal radiation delivery have limited use of the therapy. The GliaSite Radiation Therapy System (RTS) has made this effective treatment easier to use.

Learn more about the GliaSite procedure and how it is making internal radiation therapy a more viable option for brain tumor patients.

References:
1 Halligan, et al. Operation and permanent low activity 125I brachytherapy for recurrent high grade astocytomas. Int J Radiat Oncol Biol Phys. 1996;35:541-547.
2 Wen, et al. Long-term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas. Cancer. 1994;73:3029-3036.
3 Loeffler, et al. Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma. J Natl Cancer Inst. 1990;82:1918-1921.

Internal Radiation Therapy
Quick Facts
arrow The major benefit of internal radiation is that a high dose of radiation may be given directly to the tumor site, while minimizing the amount of healthy brain tissue that is exposed to radiation. This therapy is typically completed within a week versus the 6 weeks required for external beam radition therapy.
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